The Confined Impinging Jet (CIJ) and the Multi Inlet Vortex Mixer (MIVM)

In collaboration with the Department of Chemical and Biological Engineering at Princeton University, Holland Applied Technologies fabricates the Confined Impinging Jet (CIJ) and Multi Inlet Vortex Mixer (MIVM) mixers. The Confined Impinging Jet (CIJ) and Multi Inlet Vortex Mixer (MIVM) mixers have been designed and characterized in research led by Prof. Robert Prud'homme at Princeton University. His research group has produced a number of articles highlighting their use in the production of nanoparticles using scalable processing techniques.

Read more in our blog here!

Application Background

The application of nanoparticles in modern medicine is a rapidly developing field of study. Nanoprecipitation is a common fabrication technique used for encapsulation of both hydrophilic (i.e. having a tendency to mix with, dissolve in, or be wetted by water) and hydrophobic (i.e. tending to repel or fail to mix with water) drugs in nanoparticles. Flash NanoPrecipitation (FNP) provides a simple, rapid and scalable technique to form these drug nanoparticles. Read more from our blog here!



Confined Impinging Jet (CIJ)

The Confined Impinging Jet (CIJ) is the simplest mixer design for FNP and permits mixing of two streams in a scalable and continuous fashion.

Multi Inlet Vortex Mixer (MIVM)

The Multi Inlet Vortex Mixer (MIVM) was also developed to enable up to four different stream inputs while still achieving the rapid micromixing required for uniform particle formation. The MIVM requires a mixer stand to enable uniform depression of the syringes.

The MIVM Mixers & Mixer Stand